One problem related to automatic transmission has been reported for the 2004 Mercedes Benz E500. The most recently reported issues are listed below.
Engine check light illuminated. Driver put vehicle into driver and it would only go backwards. Took vehicle to dealer, and dealer determined the need for a new transmission.
| Power Train problems | |
| Automatic Transmission problems | |
| Automatic Transmission Control Module problems | |
| Transmission Slip Out Of Gear problems | |
| Transmission Failure problems |