57 problems have been reported for the 2006 Mercedes Benz E500. The following chart shows the 15 most common problems for 2006 Mercedes Benz E500. The number one most common problem is related to the vehicle's fuel system, other with 18 problems. The second most common problem is related to the vehicle's fuel system, gasoline (11 problems).
| Problem Category | Number of Problems |
|---|---|
| Other Fuel System | |
| Gasoline Fuel System | |
| Air Bag | |
| Wheel | |
| Service Brakes | |
| Electrical System | |
| Suspension | |
| Visibility | |
| Power Train | |
| Steering | |
| Electronic Stability Control | |
| Structure | |
| Engine And Engine Cooling | |
| Seat Belt | |
| Equipment |
The following chart shows the number of problems reported during each of the service years since the debut of the 2006 Mercedes Benz E500 in 2006.
| Service Year | Number of Problems |
|---|---|
| 2026 | |
| 2025 | |
| 2024 | |
| 2023 | |
| 2022 | |
| 2021 | |
| 2020 | |
| 2019 | |
| 2018 | |
| 2017 | |
| 2016 | |
| 2015 | |
| 2014 | |
| 2013 | |
| 2012 | |
| 2011 | |
| 2010 | |
| 2009 | |
| 2008 | |
| 2007 | |
| 2006 |
When making the decision between buying a new or used Mercedes Benz E500, the following table can be used to compare the 2006 Mercedes Benz E500 with the Mercedes Benz E500 from other model years. Note that the number of problems reported for the 2006 E500 is 57 while the average number of problems reported for the 7 model years of the Mercedes Benz E500 is 75.