One problem related to transmission not go into gear has been reported for the 2007 Mercedes Benz E63. The most recently reported issues are listed below.
Upon exiting the freeway and coming to a complete stop, vehicle was unable to accelerate as usual. Accelleration was very slow and without power. Upon looking at gauge cluster, the vehicle shifted itself into 5th gear it seems. Using the paddle shifter I then proceeded to downshift the transmission to 1st gear to pull away from stop. Car remained in automatic mode, but was not shifting out of gear. Cluster displays automatic comfort mode, but would not leave from what it seems 2nd gear. Stop engine and restart car, drive around and car will not shift out of gear. Upon searching the internet this is a very very common issue with all 7 speed automatic transmissions offered by Mercedes Benz. They have not assumed responsibility for a defect in part. Many have spent thousands of dollars diagnosing and repairing transmission related issues which revolve around this sub par transmission. If you search online for conductor plate, mercedes you will find countless people who have been dealing with transmission failure's due to this faulty part. This issue affects all mercedes 7 speed transmissions and as seen through online search is a world wide issue. I have read about this in the uk, australia, south America, as well as in the USA.