One problem related to automatic transmission control module has been reported for the 2006 Mercedes Benz S500. The most recently reported issues are listed below.
My transmission would not shift out of second gear. I turned it off and back on and it did not clear. I got a "pre-safe unavailable" message. I did some research and learned this is a "transmission control module" failure. It is very unsafe in that the car cannot keep up with traffic and is a danger to myself and others.
| Automatic Transmission problems | |
| Automatic Transmission Control Module problems | |
| Power Train problems |