One problem related to door latch has been reported for the 2000 Nissan Frontier. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Nissan Frontier based on all problems reported for the 2000 Frontier.
While driving with child in front seat due to lack of room in rear, had an on/off air bag switch. Child was able to release door lock & handle & door flew open. No child proof safe lock on front passenger's door. Nothing in owner's manual & dealership did mention child proof locks.