One problem related to transmission not go into gear has been reported for the 2010 Nissan Frontier. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Nissan Frontier based on all problems reported for the 2010 Frontier.
Noticed e-brake no longer holding. Took to local shop. Told me need new e-brake pads and rear axle bearings, seals. Apparently bearing seals failed and gear oil saturated brake pads. Took to dealer to fix bearings and seals under warranty (though they charged me for the brake pad replacement that was a direct result). A little online search reveals the bearing problem common on Frontiers, a result of improper axle venting. Apparently there was a retrofit part that Nissan sold to address this that has since been pulled from the parts offering.