One problem related to transmission slip out of gear has been reported for the 2006 Nissan Murano. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Nissan Murano based on all problems reported for the 2006 Murano.
2006 Nissan Murano now with 45000 miles on it. Since less than 5k mi, the car does 2 things that may be in relation to each other: 1) when driving at constant speed on flat road between 40 & 70+ mph, the rpm's will jump up 500-1000rpms for a brief moment- almost feels and sounds like the engine is slipping out of gear and then back in. Or could be that it detects a slight pressure on pedal (linkage/sender whatever) and downshifts then jumps back down? it does this with cruise control on as well. 2) also, acceleration is sluggish when leisurely proceeding from a stop, or very slow speed (say making a 90 degree turn from a stop of slow pace). While pushing on pedal, rpms and engine will actually decrease to about 1000-1500rps causing car to lag (big safety issue for I have almost been hit by other cars due to this). Does not do if I do a hard accelerate (but I don't drive that way. . . Jack rabbit starts). Dealership confirmed #1 and replaced tranny. Still did it both problems. Dealership replaced computer for tranny. Still does both, but #1 does not happen as often (used to happen 3+ times in a 15 minute period of less, not does 1-3x per hour maybe- I have stopped tracking). I let the dealership know when I bring for service, but I give up- car is out of warranty now. I'll return the lease. Too bad- love the car, just feel there is something very wrong that they weren't able to find. I have found other reports of same like problems.