One problem related to axle shaft has been reported for the 2008 Nissan Titan. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2008 Nissan Titan based on all problems reported for the 2008 Titan.
Took my Titan in for routine maintenance and the service person noticed that the right and left rear axle seals are leaking. The service person found a technical service bulletin (ntb-10-032) for this problem and bulletin says to replace the axle shaft assembly with a newly designed assembly. The leaking gear oil can easily get on the rear brakes and make them fail. This is truly a safety issue, not just a minor defect.