One problem related to differential unit has been reported for the 2000 Nissan Xterra. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Nissan Xterra based on all problems reported for the 2000 Xterra.
Rear differential had loud whine. Dealer replaced under warranty at 700-1500 miles. Replacement differential now starting to whine at 15000 miles. Driveline clunks when stopping and accelerating, suspected due to slack in transmission, universal joints, or rear end.