One problem related to differential unit has been reported for the 2010 Nissan Xterra. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Nissan Xterra based on all problems reported for the 2010 Xterra.
At a little over 180,000 miles need a new rear differential. Read on an Xterra forum the spthider gears were not heat treated properly by the manufacturer which causes rear differentials to fail. The vehicle was never driven off road or towed anything. It should not have failed.