One problem related to warnings has been reported for the 2022 Toyota 4Runner. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2022 Toyota 4Runner based on all problems reported for the 2022 4Runner.
I purchased a 2022 Toyota 4runner and 9 days later the wiring harness was destroyed by rodents most like squirrels. Toyota switched to soy based wire insulation without taking precautions in the design to protect the wiring from rodents attracted to the insulation material. The resulting damage cost $8000 to repair and it will take months for the harness to be in stock. This failure caused all safety features to be disabled leaving the vehicle without standard safety functions.