One problem related to mass air flow sensor has been reported for the 2006 Toyota Highlander Hybrid. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Toyota Highlander Hybrid based on all problems reported for the 2006 Highlander Hybrid.
While driving on i40 just after leaving i17 at flagstaff, az, during heavy rainstorm, vehicle decelerated abruptly to about 45 mph (while on cruise control set at 65), managed to pull off at next off ramp and car died completely about halfway up offramp (country club road exit). Warning messages included "check hybrid system", "check 4wd system", and "check avs system". After calling findlay Toyota in flagstaff and while waiting for tow truck, turned system off for a few minutes and attempted restart which was successful and drove to Toyota dealership. After 2 days of diagnostic checks and technician calls with Toyota, they tried to tell me problem was dirty mass air flow sensor. This vehicle had received recall notice and had inverter and avs system replaced at a little over 100,000 miles. Extreme safety hazard with power system failure on interstate in rainstorm surrounded by 18 wheelers.