One problem related to software has been reported for the 2016 Acura MDX. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2016 Acura MDX based on all problems reported for the 2016 MDX.
When driving around 75 mph on the interstate I went to switch lanes and when pressing the accelerator nothing happened and acceleration was not possible. All warning lights came on, including all wheel drive system problem, emission system problem, all wheel drive system problem, transmission system problem. Check engine and sh-awd. The power steering and brakes still worked and was extremely lucky to get the car to the shoulder without getting injured or killed. Had car towed to chattanooga Acura dealer. Car was operating normally when they received it. Acura tech support advised dealer to replace transmission and transmission control module (tcm). Also was told Acura is working on a software update for the tcm but it is not available yet but I have little confidence in the fix and little confidence that this won't reoccur. Strongly considering replacing the car.