One problem related to transmission noise has been reported for the 2016 Acura MDX. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2016 Acura MDX based on all problems reported for the 2016 MDX.
Before sharing the details, you should know that this could be a deadly safety matter. If a transmission fails at highway speeds (or any speed), the vehicle loses power and could very easily get crushed by an 18-wheeler. A driver and/or a whole family could die. You should go after Acura before someone has to die as a result of Acura's negligence. My 2016 Acura Mdx had its first transmission replacement in October 2016 at around 14,000 miles and about 18 months into ownership. I had purchased the vehicle as a brand new car from an Acura dealer. I am the only owner, and it has been "babied" and received proper maintenance from Acura dealer service shops only. Leading up to the 1st transmission replacement, the vehicle was making awful "chirping" noises upon slight acceleration at slow speeds. After the 1st transmission replacement, all seemed fine until recently. At around 38,000 miles (spring 2019, still barely within the 4 year warranty), the vehicle began to exhibit identical symptoms. At 39,000 miles, the Mdx received its 2nd transmission replacement. On the very day that I picked it up from the 2nd transmission replacement repair work, the Mdx started making far worse noises than before the repair work. It is back in the shop again and Acura seems to be at a complete loss for how to fix it properly for a 3rd time! there are many Acura/Honda technical service bulletins about transmission issues on these and Acura/Honda-related vehicles which use the same transmission. It is clearly a well-known problem putting countless drivers/passengers at physical risk or financial risk.