One problem related to differential unit has been reported for the 2000 Chevrolet Astro. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Chevrolet Astro based on all problems reported for the 2000 Astro.
Front differential failure on a 2000 chevy Astro awd with 63k miles. The total differential rebuild was required due to the bearing failure. I believe this failure could have caused a front wheel lock-up if the problem was not detected in time.