Two problems related to axle shaft seal have been reported for the 2000 Dodge Ram 2500. The most recently reported issues are listed below.
Front wheel bearings became defective shortly after purchase. Also, spindles were too small, and master cylinder and both seals had to be replaced.
Oil leaked out of the rear axle onto the brakes which was due to a defective rear axle seal. The oil saturated the brakes which caused them to lock up when applied.