One problem related to spare tire has been reported for the 2000 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford E-350 based on all problems reported for the 2000 E-350.
Spare tire fell from holder.
| Tire Tread/belt problems | |
| Tire problems | |
| Tire Blowout problems | |
| Spare Tire problems | |
| Tire Sidewall problems |