One problem related to axle hubs has been reported for the 2001 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-350 based on all problems reported for the 2001 E-350.
Hub assembly failed while driving and caused tire to come off.
| Automatic Transmission problems | |
| Axle Hubs problems | |
| Transmission Failure problems |