One problem related to transmission failure has been reported for the 2001 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-350 based on all problems reported for the 2001 E-350.
Transmission failed. The consumer stated the part in the transmission was redesigned and known to prematurely fail.
| Automatic Transmission problems | |
| Axle Hubs problems | |
| Transmission Failure problems |