One problem related to alternator/generator/regulator has been reported for the 2000 Ford E-450. The most recently reported issues are listed below.
2000 Ford e450 caught on fire while driving. Consumer pulled over to the side of the roadway and parked on the berm and vehicle became engulfed in flames. The alternator caught on fire in the engine compartment, which caused the fire. Ohio traffic crash report # 19-0415-91. Updated 04/15/10.