One problem related to front suspension leaf spring u-bolt has been reported for the 2000 Ford E-450. The most recently reported issues are listed below.
While driving two u-bolts on the left side of the vehicle broke, causing the vehicle to lean, a tire blewout and created a hole in the bottom of the ambulance, the attorney general for the state of minnesota wrote in behalf of the rushford community ambulance service, the vehicle was equipped with a velvet ride suspension.
| Suspension problems | |
| Front Suspension Leaf Spring U-bolt problems |