One problem related to body has been reported for the 2002 Ford E-450. The most recently reported issues are listed below.
I was driving down interstate 90 in south dakota at approx 70mph when a vehicle behind me flashed his lights. I pulled over and dragging behind me by only one hydraulic line was the rear leveling system. This assembly is about 5 feet long and has two hydraulic jacks one on each end. My guess is this weighs over 70lbs. Had this broken loose in the interstate at that speed god only knows what damage that could have caused. . The undamaged bolts were still in the frame. . (see photo 1) it appears to have just come loose over time. . With any kind of lock washer under the nuts or locking system this should never have happened. I disconnected the remaining hydraulic line and put the unit in the storage compartment in the camper(see photo 2).