One problem related to electrical system has been reported for the 2004 Ford E-450. The most recently reported issues are listed below.
Ford e450 front blower motor switch failure on transit buses used for public transportation. The consumer stated the problem is not isolated to one vehicle and is being found routinely in all the vehicles of this type in his fleet as the switches routinely overheat. One of the vehicles caught fire as a result of the faulty switch.
| Wiring problems | |
| Electrical System problems | |
| Starter problems |