One problem related to engine and engine cooling has been reported for the 2005 Ford E-450. The most recently reported issues are listed below.
This vehicle is a motorhome, build on the 2005 e450 cab/chassis with a gas v10 engine. While driving in a single lane construction zone on the interstate the electronic throttle body system failed, and the engine suddenly stopped responding to the accelerator pedal. As a result the vehicle suddenly lost power and slowed to a very very low speed (a few inches per second). As traffic approached and built up behind I inched the vehicle onto the shoulder. The vehicle was unable to move under it's own power any further and required a tow. It was an extremely dangerous situation on a crowded highway, in a construction zone, with my family.