One problem related to cruise control has been reported for the 2011 Ford E-450. The most recently reported issues are listed below.
On two occasions, over the past 2 years, while driving on an interstate, I have had the "wrench" light come on, on the dash display. This is caused by me using the cruise control, but when I hit the brake to release the cruise control, then step on the gas pedal to bring it back up to speed, the light appears and I go into "limp mode". Once I pull over and stop the engine, apparently this re-sets the system, and the vehicle drives okay. I have been told by a Ford tech that this is the electronic throttle control and that it may be normal, but I feel it is too sensitive. I am wondering if it should have a recall on it.