One problem related to radiator hose has been reported for the 2003 Ford E-550. The most recently reported issues are listed below.
My husband was having a routine oil change on his 2003 f-350 Ford diesel when the technician noticed he had a radiator leak, there was a hole in a radiator hose. The large dealership was out of stock of replacement hoses. (there's a clue that this is a widespread problem) they decided to pull one from one of the used trucks in stock and had to check three before they found one without a hole (there's a second clue) I found the following on-line "so I took my truck in for a coolant leak. . More like an added drain in a 3" hose that to me looks like the return under the engine. This hose is located in very close proximity to the steering box. . . . . Yep. . . A hole was worn in this hose from the steering. . . " this indicates to me that there is a design flaw placing the radiator hose too close to the steering mechanism. Overheating and stranded motorists constitutes a safety issue.