One problem related to engine engine control module (ecu/ecm) software has been reported for the 2006 Ford Escape. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford Escape based on all problems reported for the 2006 Escape.
Code p0351, p0352, p0353, p0354, p0355, p0356. Vehicle shut down on the interstate on the way home for work, 2½ hours from home. And will not restart. Pcm most likely the problem.