One problem related to engine knocking noise has been reported for the 2006 Ford Escape Hybrid. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford Escape Hybrid based on all problems reported for the 2006 Escape Hybrid.
I was driving at 55mph on a county road. All of a sudden the engine started to make a banging noise and I lost most power. I was able to limp into a oil change place. They looked at the oil and it was nearly empty. I have always changed the oil on time and done all other maintenance on this car. There was no apparent oil leak and no sign of burning oil. I had checked the oil about 300 miles prior. The oil just disappeared and the engine threw a rod necessitating a new engine. Estimated repair cost 5-6k. I have read of at least 21 other people who experienced the exact same problem; the oil just disappeared and the engine throws a rod. There is obviously a defect in this engine. I was lucky that I was driving on a country road and not a freeway and had a place to pull over.