Two problems related to horn assembly have been reported for the 2006 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford F-150 based on all problems reported for the 2006 F-150.
Smart junction box failed. Causing interior, dash and back lights not to light and including the horn not to work. When trying to replace the fuse it would blow the fuse and smoke. It is in the shop now to have the Smart junction box replaced. Fuses started blowing. At first it was the radio and the fuse was replaced then the others started to blow.
Horn didn't blow loud enough and I hit a grasshopper. Took the grasshopper to the emergency vet clinic for stitches. This cost me 110 dollars.