One problem related to transmission failure has been reported for the 2008 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2008 Ford F-150 based on all problems reported for the 2008 F-150.
The transmission failed at 82,000 miles, but because of the low mileage it was no longer covered under the new vehicle warranty and had to spend over $5,000 for transmission replacement out of my own pocket. The vehicle rarely used for towing and never off-road and has been treated like a baby.