One problem related to air brake disc rotor has been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
Consumer was towing a trailer and applied brakes the truck shuddered violently and the trailer almost "jack knifed". Vehicle was checked by dealer who determined that the front rotors were warping excessively due to water being splashed and the heat generated when brakes are applied. First time the rotors had to be turned was at 38k miles. The second time was at 58k miles. Ts.