One problem related to power train driveline has been reported for the 2006 Ford F-250. The most recently reported issues are listed below.
The contact owns a 2006 Ford F-250 sd. While driving between 45-70 mph, the entire vehicle shakes violently. The vehicle was taken to the dealer four different times for this failure, but it was unable to be repaired. The contact traded the vehicle in at a loss. The failure mileage was 4,806.