One problem related to brake disc pads has been reported for the 2008 Ford F-250. The most recently reported issues are listed below.
Three months after purchase of a 2008 F-250 Ford heavy duty truck, I noticed the brakes squeaking. On 4 occasions I have taken the truck for service to check for the cause of this problem. The first 3 times at the same dealership I was told that the squeak was caused by "road debris", and that nothing could be done to prevent this from recurring. ( the dealership cleaned the brake pads). On the forth occasion, the dealership reported that the brakes were fine and had 60 % capacity. This occurred on 8/3/2010. October 15, 2010 the squeaking was so loud, we took it to a third dealership where it was found that the rear brakes were severely worn and rusted. It required a sledge hammer to remove them due to the amount of corrosion that had built up. The front brakes were fine. Our concern is that there is/was a defect in the rear brakes and that this is a safety issue, since we pull a heavy trailer. We have kept the parts for further inspection at our residence. I have contacted the Ford customer care line who recommended this site. And who offered no further assistance with this problem, including how to prevent further problems.