One problem related to power train driveline has been reported for the 2008 Ford F-250. The most recently reported issues are listed below.
The rear u-joints on my 2008 Ford superduty f250 truck has been replaced twice in less than 50,000 miles, once at 24,000 miles and again at 47,000 miles. Ford has fixed the problem both time at no charge. But has not tried to determine the cause for this problem to prevent it from happening again at a increased rate. Truck now has 51,652 miles on it.