One problem related to brakes failed has been reported for the 2011 Ford F-250. The most recently reported issues are listed below.
We had just purchased this truck the day before with 19,000 miles on it and while towing a fifth wheel RV the in-dash oem trailer brake controller failed to engage trailer brakes allowing the RV to push the truck into an intersection. I've been to the dealer three times now and they cannot figure out why the trailer brake controller will not work. They have performed a "pin-test" and determined the in dash brake controller was not working so they replaced it to find the trailer brakes still do not activate when applying the brakes. It will work when manually activated with the slider however there is no trailer brake activation when the brake pedal is applied. The dealer acknowledges there is a problem but cannot figure it out. I've spent three days at the dealer thus far and im scheduled to return at 7 am tomorrow for them to work on it more. This is a serious safety issue and could cause a major accident if the truck does not safely stop towing a heavy RV. We traded an f150 for this f250 super duty for the added towing capacity however we now do not feel safe towing anything.