One problem related to transmission failure has been reported for the 2019 Ford F-250. The most recently reported issues are listed below.
Transmission failure while driving on interstate doing 70mph. Vehicle rolled to a stop in the middle of the highway. No power to move forward or back. The vehicle was placed into park and the 4wd indicator was moved from 2wd to 4wd. The vehicle didn't move forward or back. Engine running, no warning lights, all gauges in good status. Turned the vehicle off for 5 mins and back on, no changes. Vehicle dead in the water.