One problem related to warning has been reported for the 2021 Ford F-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2021 Ford F-350 based on all problems reported for the 2021 F-350.
While driving my 21 f350 my truck would go into limp mode. The climate control stopped working, passenger window stopped, blind spot monitors, along with the mirror. After running forscan it showed every code possible. After an exhaustive search I finally found the main plug under the bed just above the spare tire. The wires inside of the insulation had corroded away to the point it had to be stripped back at least 1/2 inch before getting decent wires that wouldn't crumble when touched. This is a terrible place to put a plug that controls so much.