One problem related to engine cooling system has been reported for the 2008 Ford F-550. The most recently reported issues are listed below.
Events leading up to the failure is typical over road driving. The failure is with the main cooling radiator, after about 20,000 it begins to leak at the drivers side bottom left corner. Consequences are the vehicle is not drivable until repairs are made. The truck was purchased in June 2007 and we are now having to replace the third radiator. The truck was under warranty with the first replacement, we had to pay a warranty adjustment with the second radiator. Now with the third one gone out they want us to pay for the entire replacement cost.