One problem related to transmission failure has been reported for the 2001 Ford F-650. The most recently reported issues are listed below.
While driving it was hard to shift gears. Dealerships mechanic informed the consumer that the problem pertained to transmission failure.
| Clutch problems | |
| Clutch Pedal/linkage problems | |
| Transmission Failure problems | |
| Axle Assembly problems | |
| Manual Transmission problems |