One problem related to automatic transmission has been reported for the 2000 GMC Safari. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 GMC Safari based on all problems reported for the 2000 Safari.
While driving at 45mph transmission went out. This vehicle was not any longer under warranty.
| Differential Unit problems | |
| Axle Assembly problems | |
| Transmission Slip Out Of Gear problems | |
| Automatic Transmission problems | |
| Transmission Noise problems |