One problem related to transmission slip out of gear has been reported for the 2000 GMC Safari. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 GMC Safari based on all problems reported for the 2000 Safari.
GMC Safari van year 2000 jumping out gear while on cruise control, causing the car to go into neutral and spin off the road down an embankment and hit a pole.
| Differential Unit problems | |
| Axle Assembly problems | |
| Transmission Slip Out Of Gear problems | |
| Automatic Transmission problems | |
| Transmission Noise problems |