One problem related to brake master cylinder has been reported for the 2000 GMC Sierra 2500. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 GMC Sierra 2500 based on all problems reported for the 2000 Sierra 2500.
Was driving on a local road. Brake pedal went to floor. Was able to stop and drive it home. The line above the gas tank was corroded and had to be replaced. Same thing happened in Dec. 2011. This time the line was corroded against the frame leading to the abs module. This repair hasn't been completed because of expense. I plan to replace the remainder of the lines because they are rusting inside the engine compartment leading to the master cylinder.