One problem related to brakes failed has been reported for the 2000 GMC Sierra 2500. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 GMC Sierra 2500 based on all problems reported for the 2000 Sierra 2500.
Power steering pump shaft broke, hydro boost system that controls brakes failed. The power steering pump was replaced and it failed again within a month.