One problem related to ignition coils failure has been reported for the 2000 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Honda Odyssey based on all problems reported for the 2000 Odyssey.
The spark plug blew out of the rear cylinder while driving on the highway. It sounded like a loud shot gun. This happened on July 10, 2005. Had not changed anything under hood. Contacted Honda, they would not pay to tow vehicle to dealer. The consumer fixed it himself. It massed up the ignition coil, shorted out the system, and shut the engine off.