One problem related to ignition has been reported for the 2006 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Honda Odyssey based on all problems reported for the 2006 Odyssey.
My wife left work and drove home, approximately 2miles, and advised she smelled/saw smoke coming from the rear of the vehicle. She exited the vehicle and advise the vehicle was on fire. Fire department responded and put out the fire, however the vehicle was a total loss. Local fire inspector investigated and advise the source of ignition was in the right rear of the vehicle in the area of the rear a/c unit and pbc. I contacted the manufacturer's customer service and they responded that "if your insurance company does not subrogate, there is nothing they can do. " the recent service on the vehicle was an oil change and new tires approximately one month prior.