One problem related to air conditioner has been reported for the 2012 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2012 Honda Odyssey based on all problems reported for the 2012 Odyssey.
The positive battery cable became disconnected from the battery terminal post while driving at full highway speed (75 mph)!! this resulted in complete electrical failure. I was able to pull off the road, but the door locks were locked and inoperable. Without power I was unable to unlock the doors or roll down the windows. Without power I had no air conditioning. I was trapped in the car on a hot day. The battery cable mismatch (clamp too big to tighten completely on post) is a known Odyssey problem that has been discussed on online forums. Door auto-locking problems in a variety of Honda models have also been documented. Putting the two together is a deadly mix. Without a cell phone to call my husband and 911, I and my three small dogs would have died in the hot car. This is a fatal design flaw.