One problem related to driveshaft has been reported for the 2001 Lexus RX300. The most recently reported issues are listed below.
Car was being parked when it suddenly went to max acceleration jumping the curb. The cars forward acceleration was stopped by large decorative rock in the parking median strip. Car ended up resting on the rock. Car was turned off by key. This is the only occurrence of this surge acceleration the car has exhibited to date. Car is currently at automotive shop for inspection and repairs. Car has significant drive shaft and undercarriage damage, but was drivable to nearby autoshop after being jacked off rock by tow truck.