One problem related to automatic transmission cooler has been reported for the 2004 Lexus RX330. The most recently reported issues are listed below.
Vehicle keeps making noises at around 30 mph. Root cause is that a transmission cooling line on my 2004 when under pressure bangs against the body of the vehicle. Lexus was well aware of this issue, so they re-designed the line on newer vehicle. Lexus is willing to replace the part but at owner cost. I believe this is a defect and Lexus need to replace the part under their own cost.