One problem related to engine and engine cooling has been reported for the 1999 Mercedes Benz C280. The most recently reported issues are listed below.
The vehicles fuel tank filler failed and made it difficult to fill the tank with gas. The gas came back out the filler cap although the tank didn't have a half a tank of gas. Sometimes the engine didn't turn over, and the vehicle was poor on gas.
| Engine Belts And Pulleys problems | |
| Engine Cooling System problems | |
| Engine Stall problems | |
| Engine And Engine Cooling problems | |
| Engine problems | |
| Loud Engine Noise problems |