Two problems related to power train have been reported for the 2008 Mercedes Benz E350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2008 Mercedes Benz E350 based on all problems reported for the 2008 E350.
While driving a 2008 mercedes-benz E350 on 5/21/2025 around 1:50pm, the transmission suddenly failed while I was traveling at approximately 75 mph was on highway 76. As a result of the failure, the driver's side airbag deployed unexpectedly.
The vehicle will intermittently go into limp mode with a max speed of 45mph. At a stop vehicle will not accelerate fwd unless transmission is put into park and the vehicle turned off and then re-started. Professional diagnosis suggests the transmission needs to be replaced and this is common for cars with 100k miles or more. Only a mercedes authorized technician with a real time connection to a mercedes server can properly perform this task. This is a sub par design that creates a safety hazard. The repair procedure coupled with the frequency of this serious failure makes this vehicle a lemon. Mercedes benz is totally responsible.
| Differential Unit problems | |
| Power Train problems | |
| Transmission Slip Out Of Gear problems |